“Hepatogenous Convulsions” and “Hepatic Anticonvulsant”

Febrile convulsions: intellectual progress in relation to anticonvulsant therapy and to recurrence of fits.

Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.

Convulsions associated with cocaine abuse can be life threatening and resistant to standard emergency treatment. Cocaine (75 mg/kg, i. p.) produced clonic convulsions in approximately 90% of male, Swiss-Webster mice. A variety of clinically used antiepileptic agents did not significantly protect against cocaine convulsions (e. g., diazepam and phenobarbital). Anticonvulsants in clinical practic...

Hepatic enzymes' level during chronic use of anticonvulsant drugs.

We studied retrospectively 894 adult epileptic patients treated during the period from 1983 to 1992. Hepatic enzymes abnormal values were seen in 49% (n = 438). In 22.3% (n = 200), at least 2 enzyme levels in different moments were altered. They were divided in three groups: GI with alterations at transaminases (3%, n = 6), GII with alterations at GGT and AP enzymes (72%, n = 144) and GIII with...

Phytochemical and Anticonvulsant Properties of Annona senegalensis Pers. (Annonaceae), Plant Used in Burkina Folk Medicine to Treat Epilepsy and Convulsions

Annona senegalensis Pers. (Annonaceae) is claimed in traditional medicine in Burkina Faso to be useful in the treatment of epilepsy. The present study aimed to investigate the phytochemical and pharmacological properties of the aqueous extracts of its root bark. The phytochemical analysis was performed using standard tests according to the Ciulei method. The acute toxicity was carried out in ra...

Allopurinol does not affect the anticonvulsant activity of carbamazepine and valproate in maximal electroshock-induced convulsions in mice.

Allopurinol, an inhibitor of xanthine oxidase, is indicated in the management of patients with elevated serum and urinary uric acid levels. It was also reported to be beneficial in patients with epilepsy when added to traditional antiepileptic drug. Here, we investigated the effect of allopurinol upon the electrical seizure threshold and its effect on the protective efficacy of common antiepile...